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How do 2 people with positive blood types (A+ and AB+) produce 2 children with negative blood types (A- and AB-)?

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If both parents are Rh+ and have mixed genes (+ -), then it is possible that each of them will give the - gene to their child, making the child Rh- (- -). (there is a 25% chance that the child will be Rh- and 75% chance that the child will get a positive from either one or both parents)

If one parent is Rh+ and has 2 positive genes (+ +) then it doesn't matter what the other parent is, all the children will be Rh+   Hope this helps.

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