Discuss P. McMakin's answer to: Why do my butt cheeks itch when i wear spanx or any control pants?

You may have a sensitivity to one of the components that make up the item. Kind of like people who have a sensitivity to latex and wind up with a rash after prolonged contact with plastic Band-Aids.

You could try wearing an additional garment underneath the item to protect your skin from direct contact but that seems to defeat the purpose of wearing Spanx.